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  <xs:element id="supn_QelbreeMember" abstract="true" name="QelbreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedClinicalTrialAndClinicalSupplyCostsCurrent" abstract="false" name="AccruedClinicalTrialAndClinicalSupplyCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_IncreaseDecreaseInAccruedProductReturnsAndRebates" abstract="false" name="IncreaseDecreaseInAccruedProductReturnsAndRebates" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" abstract="false" name="DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="supn_SPN830FirstCommercialAndSaleMember" abstract="true" name="SPN830FirstCommercialAndSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_CollaborativeArrangementPaymentForOptionIssueFee" abstract="false" name="CollaborativeArrangementPaymentForOptionIssueFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_IncomeTaxExpenseOnUncertainTaxPosition" abstract="false" name="IncomeTaxExpenseOnUncertainTaxPosition" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedProductReturnsAndRebatesTextBlock" abstract="false" name="AccruedProductReturnsAndRebatesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceReductions" abstract="false" name="DeferredTaxAssetsValuationAllowanceReductions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LeaseLiabilitiesNoncurrentAbstract" abstract="true" name="LeaseLiabilitiesNoncurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_SPN830RegulatoryAndCommercialActivitiesMember" abstract="true" name="SPN830RegulatoryAndCommercialActivitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AllMajorCustomersMember" abstract="true" name="AllMajorCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ScheduleOfAccruedProductReturnsAndRebatesTableTextBlock" abstract="false" name="ScheduleOfAccruedProductReturnsAndRebatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_NAMENDAXRNamzaricQuiTamLitigationMember" abstract="true" name="NAMENDAXRNamzaricQuiTamLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_FinancingLeaseCostAbstract" abstract="true" name="FinancingLeaseCostAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_FinancingLeaseCost" abstract="false" name="FinancingLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ReconciliationOfValuationAllowanceRollForward" abstract="true" name="ReconciliationOfValuationAllowanceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_UnrecognizedTaxBenefitsIncreaseResultingFromLapseOfApplicableStatuteOfLimitations" abstract="false" name="UnrecognizedTaxBenefitsIncreaseResultingFromLapseOfApplicableStatuteOfLimitations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LeaseBalanceSheetDisclosureTableTextBlock" abstract="false" name="LeaseBalanceSheetDisclosureTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_MarketBasedUnitsMember" abstract="true" name="MarketBasedUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_XADAGOMember" abstract="true" name="XADAGOMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearFour" abstract="false" name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquired" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAcquired" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NonRecourseLiabilityNoncurrent" abstract="false" name="NonRecourseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_SalesBasedContingentConsiderationLiabilityMember" abstract="true" name="SalesBasedContingentConsiderationLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_DeferredTaxLiabilitiesInfringementLegalCost" abstract="false" name="DeferredTaxLiabilitiesInfringementLegalCost" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_RightOfUseAssetObtainedInExchangeForOperatingAndFinanceLeaseLiability" abstract="false" name="RightOfUseAssetObtainedInExchangeForOperatingAndFinanceLeaseLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_MinimumGuaranteedAmountsOwedToCompany" abstract="false" name="MinimumGuaranteedAmountsOwedToCompany" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AdamasPharmaceuticalsMember" abstract="true" name="AdamasPharmaceuticalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_LesseeOperatingLeaseNumberOfRenewalOptions" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationArrangementsAcquisitionLiability" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsAcquisitionLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationLiabilityCurrentMember" abstract="true" name="BusinessCombinationContingentConsiderationLiabilityCurrentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedProductReturnsAndRebatesAbstract" abstract="true" name="AccruedProductReturnsAndRebatesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_PaymentsToAcquirePropertyPlantAndEquipmentAndDeferredLegalFees" abstract="false" name="PaymentsToAcquirePropertyPlantAndEquipmentAndDeferredLegalFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedExpensesAndOtherCurrentLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedExpensesAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_RegulatoryAndDevelopmentalContingentConsiderationLiabilityMember" abstract="true" name="RegulatoryAndDevelopmentalContingentConsiderationLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedRebates" abstract="false" name="AccruedRebates" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_OxtellarXRMember" abstract="true" name="OxtellarXRMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_APOKYNMember" abstract="true" name="APOKYNMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_EffectiveIncomeTaxRateReconciliationPermanentItemsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationPermanentItemsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_PurchasesOfConvertibleNoteHedge" abstract="false" name="PurchasesOfConvertibleNoteHedge" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_SPN830FutureSalesPerformanceMember" abstract="true" name="SPN830FutureSalesPerformanceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_LeasedAssetsMember" abstract="true" name="LeasedAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AccruedProductReturnsAndRebates" abstract="false" name="AccruedProductReturnsAndRebates" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationRightsPerShare" abstract="false" name="BusinessCombinationContingentConsiderationRightsPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="supn_EquityIncentivePlan2012Member" abstract="true" name="EquityIncentivePlan2012Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_CollaborativeArrangementThresholdForDevelopmentCostsPayments" abstract="false" name="CollaborativeArrangementThresholdForDevelopmentCostsPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationLiabilityNoncurrentMember" abstract="true" name="BusinessCombinationContingentConsiderationLiabilityNoncurrentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PurchaseCommitmentAnnualMinimumAmountCommitted" abstract="false" name="PurchaseCommitmentAnnualMinimumAmountCommitted" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ConversionCircumstanceOneMember" abstract="true" name="ConversionCircumstanceOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AllowanceForExpectedSalesDeductions" abstract="false" name="AllowanceForExpectedSalesDeductions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" abstract="false" name="IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_PerformanceBasedUnitsMember" abstract="true" name="PerformanceBasedUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodOne" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodOne" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceIncreaseFromAcquisitionAccounting" abstract="false" name="DeferredTaxAssetsValuationAllowanceIncreaseFromAcquisitionAccounting" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" abstract="false" name="DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="supn_ContractWithCustomerChangeInRefundLiability" abstract="false" name="ContractWithCustomerChangeInRefundLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ProductsShelfLife" abstract="false" name="ProductsShelfLife" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAsset" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_AccruedProductReturns" abstract="false" name="AccruedProductReturns" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ConversionCircumstanceTwoMember" abstract="true" name="ConversionCircumstanceTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_SalesReturnPeriod" abstract="false" name="SalesReturnPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="supn_DeferredTaxAssetsValuationAllowanceAdditions" abstract="false" name="DeferredTaxAssetsValuationAllowanceAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_OperatingLeaseVariableLeaseCost" abstract="false" name="OperatingLeaseVariableLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LeaseRightOfUseAsset" abstract="false" name="LeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LeaseLiabilitiesCurrentAbstract" abstract="true" name="LeaseLiabilitiesCurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_GOCOVRIMember" abstract="true" name="GOCOVRIMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_TrokendiXrMember" abstract="true" name="TrokendiXrMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_BusinessDisclosureAbstract" abstract="true" name="BusinessDisclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_MDDUSEnterprisesLLCFormerlyUSWMEnterprisesMember" abstract="true" name="MDDUSEnterprisesLLCFormerlyUSWMEnterprisesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_EmployeesConsultantsAndAdvisorsMember" abstract="true" name="EmployeesConsultantsAndAdvisorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AdamasMember" abstract="true" name="AdamasMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearThreeToYearFour" abstract="false" name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearThreeToYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_OperatingLeaseFixedLeaseCost" abstract="false" name="OperatingLeaseFixedLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearOneToYearTwo" abstract="false" name="DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateYearOneToYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilityNoncurrent" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NavitorPharmaceuticalsIncMember" abstract="true" name="NavitorPharmaceuticalsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" abstract="false" name="IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" abstract="false" name="NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DefinedContributionPlanEligibilityMinimumAge" abstract="false" name="DefinedContributionPlanEligibilityMinimumAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="supn_OperatingLeaseCostAbstract" abstract="true" name="OperatingLeaseCostAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_EmployerMatchEmployeeContributionLevelTwo" abstract="false" name="EmployerMatchEmployeeContributionLevelTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="supn_NumberOfProprietaryDevelopmentProducts" abstract="false" name="NumberOfProprietaryDevelopmentProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodTwo" abstract="false" name="BusinessCombinationContingentConsiderationArrangementsConsecutiveTwelveMonthNetSalesThresholdPeriodTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredIncomeTaxLiabilities" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredIncomeTaxLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_OsomolexERMember" abstract="true" name="OsomolexERMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_CustomerCMember" abstract="true" name="CustomerCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_CustomerAMember" abstract="true" name="CustomerAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_LeaseLiability" abstract="false" name="LeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NetOperatingLossCarryforwardUtilized" abstract="false" name="NetOperatingLossCarryforwardUtilized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_CustomerBMember" abstract="true" name="CustomerBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_RevenueFromRoyaltyAgreement" abstract="false" name="RevenueFromRoyaltyAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DeferredTaxAssetsConvertibleBondHedge" abstract="false" name="DeferredTaxAssetsConvertibleBondHedge" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_LabEquipmentAndFurnitureMember" abstract="true" name="LabEquipmentAndFurnitureMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_SalesReturnPeriodPriorToExpiration" abstract="false" name="SalesReturnPeriodPriorToExpiration" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="supn_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" abstract="false" name="ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="supn_BusinessCombinationContingentConsiderationNumberOfContingentValueRightsPerCommonShare" abstract="false" name="BusinessCombinationContingentConsiderationNumberOfContingentValueRightsPerCommonShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="supn_SeniorNotes2023Member" abstract="true" name="SeniorNotes2023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_MarketBasedPerformanceSharesMember" abstract="true" name="MarketBasedPerformanceSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ProductCandidatesMember" abstract="true" name="ProductCandidatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_MYOBLOCMember" abstract="true" name="MYOBLOCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_NumberOfProprietaryCommercialProducts" abstract="false" name="NumberOfProprietaryCommercialProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="supn_SPN830NDAApprovalMilestoneMember" abstract="true" name="SPN830NDAApprovalMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_ProceedsFromGovernmentalLoansAndGrants" abstract="false" name="ProceedsFromGovernmentalLoansAndGrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_DefinedContributionPlanEmployerMatchLevelTwo" abstract="false" name="DefinedContributionPlanEmployerMatchLevelTwo" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="supn_DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" abstract="false" name="DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_SPN830FDAAcceptanceMilestoneMember" abstract="true" name="SPN830FDAAcceptanceMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="supn_CollaborativeArrangementAgreementTerminationNoticePeriod" abstract="false" name="CollaborativeArrangementAgreementTerminationNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="supn_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferredCash" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentConsiderationTransferredCash" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="supn_StockOptionStockAppreciationRightsMember" abstract="true" name="StockOptionStockAppreciationRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PatentDefenseCostsMember" abstract="true" name="PatentDefenseCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_APOKYNAndSPN830Member" abstract="true" name="APOKYNAndSPN830Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="supn_PaymentsForProceedsFromCollaborativeArrangementInvestment" abstract="false" name="PaymentsForProceedsFromCollaborativeArrangementInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
