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  <xsd:element id="supn_DeferredTaxAssetAmortization" name="DeferredTaxAssetAmortization" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxAssetsConvertibleBondHedge" name="DeferredTaxAssetsConvertibleBondHedge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxAssetsOperatingLeaseLiability" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxAssetsRoyaltyRevenue" name="DeferredTaxAssetsRoyaltyRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxLiabilities481aAdjustment" name="DeferredTaxLiabilities481aAdjustment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" name="DeferredTaxLiabilitiesDebtDiscountOnConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxLiabilitiesInfringementLegalCost" name="DeferredTaxLiabilitiesInfringementLegalCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxLiabilitiesUnrealizedGainOnMarketableSecurities" name="DeferredTaxLiabilitiesUnrealizedGainOnMarketableSecurities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_DeferredTaxLiabilityOperatingLeaseAssets" name="DeferredTaxLiabilityOperatingLeaseAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_DefinedContributionPlanEligibilityMinimumAge" name="DefinedContributionPlanEligibilityMinimumAge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" name="DefinedContributionPlanEmployerMatchEmployeeContributionLevelOne" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_DefinedContributionPlanEmployerMatchLevelOne" name="DefinedContributionPlanEmployerMatchLevelOne" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_DefinedContributionPlanEmployerMatchLevelTwo" name="DefinedContributionPlanEmployerMatchLevelTwo" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" name="DefinedContributionPlanMaximumDiscretionaryEmployerContributionPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_EmployeesConsultantsAndAdvisorsMember" name="EmployeesConsultantsAndAdvisorsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_EmployerMatchEmployeeContributionLevelTwo" name="EmployerMatchEmployeeContributionLevelTwo" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_EquityIncentivePlan2012Member" name="EquityIncentivePlan2012Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_GainsLossesOnExtinguishmentOfOutstandingDebt" name="GainsLossesOnExtinguishmentOfOutstandingDebt" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_GainsLossesOnExtinguishmentOfOutstandingDebtAsIfConverted" name="GainsLossesOnExtinguishmentOfOutstandingDebtAsIfConverted" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncomeTaxExpenseOnUncertainTaxPosition" name="IncomeTaxExpenseOnUncertainTaxPosition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" name="IncomeTaxExpenseOnUncertainTaxPositionAlternateMinimumTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncreaseDecreaseInAccruedProductReturnsAndRebates" name="IncreaseDecreaseInAccruedProductReturnsAndRebates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncreaseDecreaseInDeferredLicensingRevenue" name="IncreaseDecreaseInDeferredLicensingRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncreaseDecreaseInFairValueDerivativeLiabilities" name="IncreaseDecreaseInFairValueDerivativeLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" name="IncreaseDecreaseInPrepaidDeferredExpenseAndOtherCurrentAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_IncrementalCommonSharesAttributableToSettlementOfInterestMakeWholeDerivatives" name="IncrementalCommonSharesAttributableToSettlementOfInterestMakeWholeDerivatives" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_InterestExpenseNonRecourseRoyaltyLiability" name="InterestExpenseNonRecourseRoyaltyLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_LabEquipmentAndFurnitureMember" name="LabEquipmentAndFurnitureMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_LeaseBalanceSheetDisclosureTableTextBlock" name="LeaseBalanceSheetDisclosureTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_LeaseDisclosureTextBlock" name="LeaseDisclosureTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_LeaseQuantitativeDisclosureTableTextBlock" name="LeaseQuantitativeDisclosureTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_LesseeOperatingLeaseLiabilities" name="LesseeOperatingLeaseLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_LesseeOperatingLeaseLiabilityPaymentsDueThereafter" name="LesseeOperatingLeaseLiabilityPaymentsDueThereafter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_MinimumGuaranteedAmountsOwedToCompany" name="MinimumGuaranteedAmountsOwedToCompany" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_NetOperatingLossCarryforwardUtilized" name="NetOperatingLossCarryforwardUtilized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_NonCashCapitalizedCostOfIntangibleAssets" name="NonCashCapitalizedCostOfIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesCurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" name="NonRecourseDebtSaleOfFutureRoyaltiesNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_NoncashOperatingLeaseCost" name="NoncashOperatingLeaseCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_NotesFaceValue" name="NotesFaceValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_NumberOfCommercialProducts" name="NumberOfCommercialProducts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_NumberOfProprietaryCommercialProducts" name="NumberOfProprietaryCommercialProducts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_NumberOfVotesPerCommonShareHeld" name="NumberOfVotesPerCommonShareHeld" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="supn_OperatingLeaseFixedLeaseCost" name="OperatingLeaseFixedLeaseCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_OperatingLeaseVariableLeaseCost" name="OperatingLeaseVariableLeaseCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_OperatingLeasesAdditionalAllowanceForTenantAndCapitalImprovement" name="OperatingLeasesAdditionalAllowanceForTenantAndCapitalImprovement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_OperatingLeasesFutureMinimumPaymentsThereafterDue" name="OperatingLeasesFutureMinimumPaymentsThereafterDue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_OperatingLeasesRentPayments" name="OperatingLeasesRentPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_OperatingLeasesRentalExpensesAnnualIncreaseInRentalPaymentsPercentage" name="OperatingLeasesRentalExpensesAnnualIncreaseInRentalPaymentsPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_OperatingLeasesRentalExpensesInitialFixedMonthlyRentalPayments" name="OperatingLeasesRentalExpensesInitialFixedMonthlyRentalPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_OverAllotmentPeriodForAdditionalPrincipalAmount" name="OverAllotmentPeriodForAdditionalPrincipalAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_OxtellarXRMember" name="OxtellarXRMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_PatentDefenseCostsMember" name="PatentDefenseCostsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023GrantedToInitialPurchasersMember" name="PercentageOf0.625ConvertibleSeniorNotesDue2023GrantedToInitialPurchasersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023Member" name="PercentageOf0.625ConvertibleSeniorNotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_PercentageOf0.625ConvertibleSeniorNotesDue2023OverAllotmentOptionMember" name="PercentageOf0.625ConvertibleSeniorNotesDue2023OverAllotmentOptionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_PrelaunchInventoryNet" name="PrelaunchInventoryNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="supn_ProductsShelfLife" name="ProductsShelfLife" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_PropertyAndEquipmentAdditionsFromUtilizationOfTenantImprovementAllowance" name="PropertyAndEquipmentAdditionsFromUtilizationOfTenantImprovementAllowance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="supn_PurchasesOfConvertibleNoteHedge" name="PurchasesOfConvertibleNoteHedge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_PurchasesOfConvertibleNoteHedgesNetOfTax" name="PurchasesOfConvertibleNoteHedgesNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_ResearchAndDevelopmentExpensesAndRelatedAccruedResearchAndDevelopmentExpensesPolicyTextBlock" name="ResearchAndDevelopmentExpensesAndRelatedAccruedResearchAndDevelopmentExpensesPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_RevenueFromRoyaltyAgreement" name="RevenueFromRoyaltyAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_SalesReturnPeriod" name="SalesReturnPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_SalesReturnPeriodPriorToExpiration" name="SalesReturnPeriodPriorToExpiration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_ScheduleOfAccruedProductReturnsAndRebatesTableTextBlock" name="ScheduleOfAccruedProductReturnsAndRebatesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" name="ScheduleOfPropertyPlantAndEquipmentComponentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_SelfInsuranceLiability" name="SelfInsuranceLiability" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingNumberOfInstallmentsFromFirstAnniversaryOfGrantDate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedForfeitureRate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedForfeitureRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodSharesConversionOfConvertibleNotes" name="StockIssuedDuringPeriodSharesConversionOfConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodValueConversionOfConvertibleNotes" name="StockIssuedDuringPeriodValueConversionOfConvertibleNotes" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" name="StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_StockOptionStockAppreciationRightsMember" name="StockOptionStockAppreciationRightsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance" name="StockholdersEquityIncludingPortionAttributableToNoncontrollingInterestAdjustedBalance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="supn_ThresholdLimitForMedicalClaim" name="ThresholdLimitForMedicalClaim" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="supn_TrokendiXrMember" name="TrokendiXrMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="supn_UnrecognizedTaxBenefitsChangeInTaxRates" name="UnrecognizedTaxBenefitsChangeInTaxRates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="supn_UnsettledPurchaseOfMarketableSecuritiesIncludedInAccruedExpenses" name="UnsettledPurchaseOfMarketableSecuritiesIncludedInAccruedExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
</xsd:schema>
