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Related-Party Transactions </font><!-- COMMAND=ADD_ETF,"A" --></b></font></p> <p style="FONT-FAMILY: arial"><font size="2">In May 2009, the Company entered into an amendment to a license agreement with Shire&#160;LLC, a holder of Series&#160;A Preferred Stock, whereby Shire&#160;LLC and its affiliates paid the Company a one-time, lump-sum payment of $36.9&#160;million in return for a fully paid-up license for one of its products that utilizes the Company's proprietary technologies. All four criteria necessary to recognize revenue in accordance with Accounting Standards Codification 605-10-S25, </font><font size="2"><i>Revenue Recognition&#160;&#8212; Overall&#160;&#8212; Recognition</i></font><font size="2">, were met during 2009 related to this transaction (see Note&#160;3). 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Management's Plans as to Continuing as a Going Concern </font><!-- COMMAND=ADD_ETF,"A" --></b></font></p> <p style="FONT-FAMILY: arial"><font size="2">The accompanying financial statements have been prepared on a going-concern basis, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. Since inception, the Company has incurred, and continues to incur, significant losses from operations. The Company needs to raise additional capital to continue its business operations as currently conducted and to fund deficits in operating cash flows. </font></p> <p style="FONT-FAMILY: arial"><font size="2">As described more fully in Note&#160;7, the Company drew down $30.0&#160;million under a secured credit facility (the Facility) during 2011. There is no remaining borrowing capacity under the Facility. 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